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==== | ==Crystal structure of human Bromodomain containing protein 4 (BRD4) in complex with BCLTF1== | ||
<StructureSection load='7rjr' size='340' side='right'caption='[[7rjr]]' scene=''> | <StructureSection load='7rjr' size='340' side='right'caption='[[7rjr]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7rjr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RJR FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rjr OCA], [https://pdbe.org/7rjr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rjr RCSB], [https://www.ebi.ac.uk/pdbsum/7rjr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rjr ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rjr OCA], [https://pdbe.org/7rjr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rjr RCSB], [https://www.ebi.ac.uk/pdbsum/7rjr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rjr ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Fedorov E]] | ||
[[Category: Ghosh A]] | |||
[[Category: Islam K]] | |||
Revision as of 06:13, 8 September 2022
Crystal structure of human Bromodomain containing protein 4 (BRD4) in complex with BCLTF1Crystal structure of human Bromodomain containing protein 4 (BRD4) in complex with BCLTF1
Structural highlights
Disease[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2] Function[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). References
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