3vr0: Difference between revisions

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<StructureSection load='3vr0' size='340' side='right'caption='[[3vr0]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='3vr0' size='340' side='right'caption='[[3vr0]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3vr0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrfu Pyrfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VR0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3vr0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VR0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3gaa|3gaa]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PF1142 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=186497 PYRFU])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vr0 OCA], [https://pdbe.org/3vr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vr0 RCSB], [https://www.ebi.ac.uk/pdbsum/3vr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vr0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vr0 OCA], [https://pdbe.org/3vr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vr0 RCSB], [https://www.ebi.ac.uk/pdbsum/3vr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vr0 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q8U1R3_PYRFU Q8U1R3_PYRFU]
Assembly of the eukaryotic 20S proteasome is an ordered process involving several proteins operating as proteasome assembly factors including PAC1-PAC2 but archaeal 20S proteasome subunits can spontaneously assemble into an active cylindrical architecture. Recent bioinformatic analysis identified archaeal PAC1-PAC2 homologs PbaA and PbaB. However, it remains unclear whether such assembly factor-like proteins play an indispensable role in orchestration of proteasome subunits in archaea. We revealed that PbaB forms a homotetramer and exerts a dual function as an ATP-independent proteasome activator and a molecular chaperone through its tentacle-like C-terminal segments. Our findings provide insights into molecular evolution relationships between proteasome activators and assembly factors.
 
An archaeal homolog of proteasome assembly factor functions as a proteasome activator.,Kumoi K, Satoh T, Murata K, Hiromoto T, Mizushima T, Kamiya Y, Noda M, Uchiyama S, Yagi H, Kato K PLoS One. 2013;8(3):e60294. doi: 10.1371/journal.pone.0060294. Epub 2013 Mar 21. PMID:23555947<ref>PMID:23555947</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3vr0" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Pyrfu]]
[[Category: Pyrococcus furiosus DSM 3638]]
[[Category: Hiromoto, T]]
[[Category: Hiromoto T]]
[[Category: Kamiya, Y]]
[[Category: Kamiya Y]]
[[Category: Kato, K]]
[[Category: Kato K]]
[[Category: Kumoi, K]]
[[Category: Kumoi K]]
[[Category: Mizushima, T]]
[[Category: Mizushima T]]
[[Category: Murata, K]]
[[Category: Murata K]]
[[Category: Noda, M]]
[[Category: Noda M]]
[[Category: Satoh, T]]
[[Category: Satoh T]]
[[Category: Uchiyama, S]]
[[Category: Uchiyama S]]
[[Category: Yagi, H]]
[[Category: Yagi H]]
[[Category: Proteasome]]
[[Category: Proteasome activator]]
[[Category: Protein binding]]

Latest revision as of 11:41, 20 March 2024

Crystal structure of Pyrococcus furiosus PbaB, an archaeal proteasome activatorCrystal structure of Pyrococcus furiosus PbaB, an archaeal proteasome activator

Structural highlights

3vr0 is a 4 chain structure with sequence from Pyrococcus furiosus DSM 3638. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q8U1R3_PYRFU

3vr0, resolution 2.20Å

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OCA
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