1hs7: Difference between revisions

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-[[Image:1hs7.gif|left|200px]]
+{{Seed}}
+[[Image:1hs7.png|left|200px]]
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 {{STRUCTURE_1hs7|  PDB=1hs7  |  SCENE=  }}
-'''VAM3P N-TERMINAL DOMAIN SOLUTION STRUCTURE'''
+===VAM3P N-TERMINAL DOMAIN SOLUTION STRUCTURE===
-==Overview==
+<!--
-Syntaxins and Sec1/munc18 proteins are central to intracellular membrane fusion. All syntaxins comprise a variable N-terminal region, a conserved SNARE motif that is critical for SNARE complex formation, and a transmembrane region. The N-terminal region of neuronal syntaxin 1A contains a three-helix domain that folds back onto the SNARE motif forming a 'closed' conformation; this conformation is required for munc18-1 binding. We have examined the generality of the structural properties of syntaxins by NMR analysis of Vam3p, a yeast syntaxin essential for vacuolar fusion. Surprisingly, Vam3p also has an N-terminal three-helical domain despite lacking apparent sequence homology with syntaxin 1A in this region. However, Vam3p does not form a closed conformation and its N-terminal domain is not required for binding to the Sec1/munc18 protein Vps33p, suggesting that critical distinctions exist in the mechanisms used by syntaxins to govern different types of membrane fusion.
+The line below this paragraph, {{ABSTRACT_PUBMED_11224573}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11224573 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11224573}}
 ==About this Structure==
-HS7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HS7 OCA].
+HS7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HS7 OCA].
 ==Reference==
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 [[Category: Yamaguchi, T.]]
 [[Category: Up-and-down three-helix bundle insertion preceding proline in an alpha-helix]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:10:52 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 08:36:45 2008''