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==Cytoplasmic dynein-1 motor domain AAA1, AAA2, and AAA3 subunits== | ==Cytoplasmic dynein-1 motor domain AAA1, AAA2, and AAA3 subunits== | ||
<StructureSection load='7z8h' size='340' side='right'caption='[[7z8h]]' scene=''> | <StructureSection load='7z8h' size='340' side='right'caption='[[7z8h]], [[Resolution|resolution]] 3.41Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z8H FirstGlance]. <br> | <table><tr><td colspan='2'>[[7z8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z8H FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z8h OCA], [https://pdbe.org/7z8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z8h RCSB], [https://www.ebi.ac.uk/pdbsum/7z8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z8h ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z8h OCA], [https://pdbe.org/7z8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z8h RCSB], [https://www.ebi.ac.uk/pdbsum/7z8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z8h ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[[https://www.uniprot.org/uniprot/DYHC1_HUMAN DYHC1_HUMAN]] Autosomal dominant childhood-onset proximal spinal muscular atrophy without contractures;Autosomal dominant non-syndromic intellectual disability;Autosomal dominant Charcot-Marie-Tooth disease type 2O. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/DYHC1_HUMAN DYHC1_HUMAN]] Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074).<ref>PMID:27462074</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Carter AP]] | [[Category: Carter AP]] | ||
[[Category: Chaaban S]] | [[Category: Chaaban S]] | ||
Revision as of 07:19, 8 September 2022
Cytoplasmic dynein-1 motor domain AAA1, AAA2, and AAA3 subunitsCytoplasmic dynein-1 motor domain AAA1, AAA2, and AAA3 subunits
Structural highlights
Disease[DYHC1_HUMAN] Autosomal dominant childhood-onset proximal spinal muscular atrophy without contractures;Autosomal dominant non-syndromic intellectual disability;Autosomal dominant Charcot-Marie-Tooth disease type 2O. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Function[DYHC1_HUMAN] Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074).[1] References
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