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<StructureSection load='3tfp' size='340' side='right'caption='[[3tfp]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3tfp' size='340' side='right'caption='[[3tfp]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3tfp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TFP FirstGlance]. <br>
<table><tr><td colspan='2'>[[3tfp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TFP FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=03L:2-({2-CHLORO-6-[(2,4-DICHLOROPHENYL)SULFANYL]BENZYL}CARBAMOYL)BENZOIC+ACID'>03L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">crtM ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=03L:2-({2-CHLORO-6-[(2,4-DICHLOROPHENYL)SULFANYL]BENZYL}CARBAMOYL)BENZOIC+ACID'>03L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tfp OCA], [https://pdbe.org/3tfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tfp RCSB], [https://www.ebi.ac.uk/pdbsum/3tfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tfp ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tfp OCA], [https://pdbe.org/3tfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tfp RCSB], [https://www.ebi.ac.uk/pdbsum/3tfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tfp ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/CRTM_STAAU CRTM_STAAU]
Double whammy! Small molecules that inhibit Staphylococcus aureus dehydrosqualene synthase (CrtM) or host squalene synthase (SQS) are of interest as novel, innate immunity-based therapeutics, blocking virulence or stimulating antibacterial neutrophil extracellular trap (NET) formation. The discovery of leads that do both represents a new route to treating staph infections.
 
Dual dehydrosqualene/squalene synthase inhibitors: leads for innate immune system-based therapeutics.,Lin FY, Zhang Y, Hensler M, Liu YL, Chow OA, Zhu W, Wang K, Pang R, Thienphrapa W, Nizet V, Oldfield E ChemMedChem. 2012 Apr;7(4):561-4. doi: 10.1002/cmdc.201100589. Epub 2012 Jan 30. PMID:22290830<ref>PMID:22290830</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3tfp" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Squalene synthase|Squalene synthase]]
*[[Squalene synthase|Squalene synthase]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lin, F Y]]
[[Category: Staphylococcus aureus]]
[[Category: Liu, Y L]]
[[Category: Lin F-Y]]
[[Category: Oldfield, E]]
[[Category: Liu Y-L]]
[[Category: Zhang, Y]]
[[Category: Oldfield E]]
[[Category: Head-to-head prenyl synthase]]
[[Category: Zhang Y]]
[[Category: Transferase-transferase inhibitor complex]]

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