1hmh: Difference between revisions

Revision as of 08:24, 1 July 2008

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File:1hmh.png

Template:STRUCTURE 1hmh

THREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYMETHREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYME

Template:ABSTRACT PUBMED 7969422

About this StructureAbout this Structure

Full crystallographic information is available from OCA.

ReferenceReference

Three-dimensional structure of a hammerhead ribozyme., Pley HW, Flaherty KM, McKay DB, Nature. 1994 Nov 3;372(6501):68-74. PMID:7969422

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OCA

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-'''THREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYME'''
+===THREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYME===
-==Overview==
+<!--
-The hammerhead ribozyme is a small catalytic RNA motif made up of three base-paired stems and a core of highly conserved, non-complementary nucleotides essential for catalysis. The X-ray crystallographic structure of a hammerhead RNA-DNA ribozyme-inhibitor complex at 2.6 A resolution reveals that the base-paired stems are A-form helices and that the core has two structural domains. The first domain is formed by the sequence 5'-CUGA following stem I and is a sharp turn identical to the uridine turn of transfer RNA, whereas the second is a non-Watson-Crick three-base-pair duplex with a divalent-ion binding site. The phosphodiester backbone of the DNA inhibitor strand is splayed out at the phosphate 5' to the cleavage site. The structure indicates that the ribozyme may destabilize a substrate strand in order to facilitate twisting of the substrate to allow cleavage of the scissile bond.
+The line below this paragraph, {{ABSTRACT_PUBMED_7969422}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 7969422 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_7969422}}
 ==About this Structure==
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 [[Category: Dna-rna hammerhead ribozyme]]
 [[Category: Loop]]
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