Syntenin: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
The 3D structure of the complex of SYNT PDZ1 and PDZ2 domains with a syndecan peptide shows the simultaneous binding to the two domains<ref>PMID:16533050</ref>. | The 3D structure of the complex of SYNT PDZ1 and PDZ2 domains with a syndecan peptide shows the <scene name='91/916387/Cv/2'>simultaneous binding to the two domains</scene><ref>PMID:16533050</ref>. The peptide forms a β strand which runs antiparallel to the PDZ β strand. | ||
==Syntenin 3D structures== | ==Syntenin 3D structures== | ||
Revision as of 16:10, 5 July 2022
FunctionSyntenin (SYNT) is a small intracellular adaptor which together with syndecan has a role in the biogenesis of secreted vesicles or exosomes[1] RelevanceExosomes secreted by cancer cells contribute to tumor progression and metastasis and analyzing their content can help in early detection of cancer as well as of other diseases. SYNT is over-expressed in breast and gastric cancer Structural highlightsThe 3D structure of the complex of SYNT PDZ1 and PDZ2 domains with a syndecan peptide shows the [2]. The peptide forms a β strand which runs antiparallel to the PDZ β strand. Syntenin 3D structures
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ReferencesReferences
- ↑ Friand V, David G, Zimmermann P. Syntenin and syndecan in the biogenesis of exosomes. Biol Cell. 2015 Oct;107(10):331-41. doi: 10.1111/boc.201500010. Epub 2015 Jun 30. PMID:26032692 doi:http://dx.doi.org/10.1111/boc.201500010
- ↑ Grembecka J, Cierpicki T, Devedjiev Y, Derewenda U, Kang BS, Bushweller JH, Derewenda ZS. The binding of the PDZ tandem of syntenin to target proteins. Biochemistry. 2006 Mar 21;45(11):3674-83. PMID:16533050 doi:10.1021/bi052225y