Chorismate mutase: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

@@ Line 1: / Line 1: @@
-<StructureSection load='4ppv' size='340' side='right' caption='Bacillus subtilis chorismate mutase complex with chorismate, prephenate and citrulline (PDB code [[3zp7]]).' scene=''>
+<StructureSection load='2fp2' size='340' side='right' caption='Bacillus subtilis chorismate mutase complex with transition state analog (PDB code [[2fp2]]).' scene=''>
 == Function ==
-'''Chorismate mutase'''.(CHM) is a key enzyme in the biosynthesis of aromatic amino acids Phe and Tyr . CHM catalyzes the rearrangement of chorismate to prephenate which is the precursor of Phe and Tyr<ref>PMID:21638687</ref>..  CHM is divided to 2 classes: AroH class which is monofunctional and th bifunctional AroQ.
+'''Chorismate mutase'''.(CHM) is a key enzyme in the biosynthesis of aromatic amino acids Phe and Tyr . CHM catalyzes the rearrangement of chorismate to prephenate which is the precursor of Phe and Tyr<ref>PMID:21638687</ref>..  CHM is divided ןמto 2 classes: AroH class which is monofunctional and thק bifunctional AroQ.
 == Disease ==
@@ Line 11: / Line 11: @@
 == Structural highlights ==
-This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
+The 3D structure of the complex of CHM with transition state analog shows the CHM structure containing a dimer of pseudosymmetry but only the N-terminal half contains an available active site pocket.  The transition state analog is buried in the active site pocket and forms extensive H-bond network with CHM.  Arg 49 and Arg 134 which are part of this network are conserved in all the known CHMs<ref>PMID:16499927</ref>.
 </StructureSection>
 == References ==
 <references/>