1hkf: Difference between revisions

Revision as of 08:18, 1 July 2008

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File:1hkf.png

Template:STRUCTURE 1hkf

THE THREE DIMENSIONAL STRUCTURE OF NK CELL RECEPTOR NKP44, A TRIGGERING PARTNER IN NATURAL CYTOTOXICITYTHE THREE DIMENSIONAL STRUCTURE OF NK CELL RECEPTOR NKP44, A TRIGGERING PARTNER IN NATURAL CYTOTOXICITY

Template:ABSTRACT PUBMED 12791260

About this StructureAbout this Structure

1HKF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity., Cantoni C, Ponassi M, Biassoni R, Conte R, Spallarossa A, Moretta A, Moretta L, Bolognesi M, Bordo D, Structure. 2003 Jun;11(6):725-34. PMID:12791260

Page seeded by OCA on Tue Jul 1 08:18:46 2008

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OCA

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-'''THE THREE DIMENSIONAL STRUCTURE OF NK CELL RECEPTOR NKP44, A TRIGGERING PARTNER IN NATURAL CYTOTOXICITY'''
+===THE THREE DIMENSIONAL STRUCTURE OF NK CELL RECEPTOR NKP44, A TRIGGERING PARTNER IN NATURAL CYTOTOXICITY===
-==Overview==
+<!--
-Natural killer (NK) cells direct cytotoxicity against tumor or virally infected cells. NK cell activation depends on a fine balance between inhibitory and activating receptors. NKp44 is a cytotoxicity activating receptor composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. The 2.2 A crystal structure shows that the NKp44 Ig domain forms a saddle-shaped dimer, where a charged surface groove protrudes from the core structure in each subunit. NKp44 Ig domain disulfide bridge topology defines a new Ig structural subfamily. The data presented are a first step toward understanding the molecular basis for ligand recognition by natural cytotoxicity receptors, whose key role in the immune system is established, but whose cellular ligands are still elusive.
+The line below this paragraph, {{ABSTRACT_PUBMED_12791260}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_12791260}}
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 [[Category: Natural cytotoxicity receptor]]
 [[Category: Nkp44,receptor]]
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