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==Structural insight into the interactions between Lloviu virus VP30 and nucleoprotein== | ==Structural insight into the interactions between Lloviu virus VP30 and nucleoprotein== | ||
<StructureSection load='7xiv' size='340' side='right'caption='[[7xiv]]' scene=''> | <StructureSection load='7xiv' size='340' side='right'caption='[[7xiv]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XIV FirstGlance]. <br> | <table><tr><td colspan='2'>[[7xiv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lloviu_cuevavirus Lloviu cuevavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XIV FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xiv OCA], [https://pdbe.org/7xiv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xiv RCSB], [https://www.ebi.ac.uk/pdbsum/7xiv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xiv ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.498Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xiv OCA], [https://pdbe.org/7xiv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xiv RCSB], [https://www.ebi.ac.uk/pdbsum/7xiv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xiv ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/G8EFI6_LLOVA G8EFI6_LLOVA] [https://www.uniprot.org/uniprot/G8EFI1_LLOVA G8EFI1_LLOVA] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The family Filoviridae comprises many notorious viruses, such as Ebola virus (EBOV) and Marburg virus (MARV), that can infect humans and nonhuman primates. Lloviu virus (LLOV), a less well studied filovirus, is considered a potential pathogen for humans. The VP30 C-terminal domain (CTD) of these filoviruses exhibits nucleoprotein (NP) binding and plays an essential role in viral transcription, replication and assembly. In this study, we confirmed the interactions between LLOV VP30 CTD and its NP fragment, and also determined the crystal structure of the chimeric dimeric LLOV NP-VP30 CTD at 2.50 A resolution. The structure is highly conserved across the family Filoviridae. While in the dimer structure, only one VP30 CTD binds the NP fragment, which indicates that the interaction between LLOV VP30 CTD and NP is not strong. Our work provides a preliminary model to investigate the interactions between LLOV VP30 and NP and suggests a potential target for anti-filovirus drug development. | |||
Structural insights into the interactions between lloviu virus VP30 and nucleoprotein.,Sun W, Luan F, Wang J, Ma L, Li X, Yang G, Hao C, Qin X, Dong S Biochem Biophys Res Commun. 2022 Aug 6;616:82-88. doi: , 10.1016/j.bbrc.2022.05.059. Epub 2022 May 20. PMID:35649303<ref>PMID:35649303</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7xiv" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Dong | [[Category: Lloviu cuevavirus]] | ||
[[Category: Dong SS]] | |||
[[Category: Hao CY]] | |||
[[Category: Li XX]] | |||
[[Category: Luan FC]] | |||
[[Category: Ma L]] | |||
[[Category: Qin XC]] | |||
[[Category: Sun WY]] | |||
[[Category: Wang JJ]] | |||
[[Category: Yang GX]] | |||