Factor XII: Difference between revisions

Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

@@ Line 1: / Line 1: @@
 <StructureSection load='7fbp' size='340' side='right' caption='Glycosylated human factor XII protease domain (grey)  complex with cyclic peptide inhibitor (green)' scene=''>
-This is a default text for your page '''Factor XII'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
-You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
 == Function ==
+Coagulation '''factor XII''' (FXII) or '''Hageman factor''' is the zymogen of '''factor XIIa''' (FXIIa).  Factor XIIa , the active form of factor XII, is of crucial importance in fibrin formation<ref>PMID:22993391</ref> and initiates the procoagulant and proinflammatory contact system.
 == Disease ==
+FXIIa has critical role in coagulation in thromboembolic diseases.
 == Relevance ==
+Inhibition of the FXII-driven contact system may be a promising therapeutic anticoagulation treatment strategy<ref>PMID:27834692</ref>.  The choice of cyclic peptides as inhibitors of FXIIa is based on their being cell-permeable and more stable to proteolysis.
 == Structural highlights ==
-This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
+The 3D structure of the complex between human FXIIa and a cyclic peptide inhibitor<ref>PMID:34723512</ref>.shows the peptide forming intermolecular β-sheet-like hydrogen bonds with FXIIa at two regions.
+==FXII 3D structures==
+[[3D structures of FXII]]
 </StructureSection>
 == References ==
 <references/>
+[[Category:Topic Page]]