7z52: Difference between revisions
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==== | ==Human NEXT dimer - focused reconstruction of the single MTR4== | ||
<StructureSection load='7z52' size='340' side='right'caption='[[7z52]]' scene=''> | <StructureSection load='7z52' size='340' side='right'caption='[[7z52]], [[Resolution|resolution]] 3.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7z52]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z52 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z52 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z52 OCA], [https://pdbe.org/7z52 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z52 RCSB], [https://www.ebi.ac.uk/pdbsum/7z52 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z52 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z52 OCA], [https://pdbe.org/7z52 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z52 RCSB], [https://www.ebi.ac.uk/pdbsum/7z52 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z52 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/MTREX_HUMAN MTREX_HUMAN]] Component of exosome targeting complexes. Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA.<ref>PMID:17412707</ref> <ref>PMID:27871484</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Synthetic construct]] | ||
[[Category: Basquin J]] | |||
[[Category: Bonneau F]] | |||
[[Category: Conti E]] | |||
[[Category: Gerlach P]] | |||
[[Category: Lingaraju M]] | |||
[[Category: Salerno-Kochan A]] | |||