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[[Image:1hcq.gif|left|200px]]
[[Image:1hcq.png|left|200px]]


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==Overview==
{{ABSTRACT_8221895}}
The nuclear hormone receptors are a superfamily of ligand-activated DNA-binding transcription factors. We have determined the crystal structure (at 2.4 A) of the fully specific complex between the DNA-binding domain from the estrogen receptor and DNA. The protein binds as a symmetrical dimer to its palindromic binding site consisting of two 6 bp consensus half sites with three intervening base pairs. This structure reveals how the protein recognizes its own half site sequence rather than that of the related glucocorticoid receptor, which differs by only two base pairs. Since all nuclear hormone receptors recognize one or the other of these two consensus half site sequences, this recognition mechanism applies generally to the whole receptor family.


==About this Structure==
==About this Structure==
1HCQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1HCQ with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb45_1.html Estrogen Receptor]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HCQ OCA].  
1HCQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1HCQ with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb45_1.html Estrogen Receptor]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HCQ OCA].  
==Reference==
The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements., Schwabe JW, Chapman L, Finch JT, Rhodes D, Cell. 1993 Nov 5;75(3):567-78. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8221895 8221895]
[[Category: Estrogen Receptor]]
[[Category: Estrogen Receptor]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Complexed with drug]]
[[Category: Complexed with drug]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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