7ul7: Difference between revisions
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==== | ==Lineage I (Pinneo) Lassa virus glycoprotein bound to 18.5C-M30 Fab== | ||
<StructureSection load='7ul7' size='340' side='right'caption='[[7ul7]]' scene=''> | <StructureSection load='7ul7' size='340' side='right'caption='[[7ul7]], [[Resolution|resolution]] 3.59Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7ul7]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lassa_mammarenavirus Lassa mammarenavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UL7 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ul7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ul7 OCA], [https://pdbe.org/7ul7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ul7 RCSB], [https://www.ebi.ac.uk/pdbsum/7ul7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ul7 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ul7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ul7 OCA], [https://pdbe.org/7ul7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ul7 RCSB], [https://www.ebi.ac.uk/pdbsum/7ul7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ul7 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/Q9IMJ0_LASV Q9IMJ0_LASV]] Glycoprotein G1: interacts with the host receptor.[HAMAP-Rule:MF_04084] Glycoprotein G2: class I viral fusion protein that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm. Membrane fusion is mediated by irreversible conformational changes induced upon acidification in the endosome.[HAMAP-Rule:MF_04084] Stable signal peptide (SSP): cleaved and functions as a signal peptide. In addition, it is also retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion.[HAMAP-Rule:MF_04084] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Lassa mammarenavirus]] | ||
[[Category: Buck TK]] | |||
[[Category: Enriquez AS]] | |||
[[Category: Hastie KM]] | |||