7zjh: Difference between revisions

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-'''Unreleased structure'''
-The entry 7zjh is ON HOLD  until Paper Publication
+==TRPV2-C16+Pro-2==
+<StructureSection load='7zjh' size='340' side='right'caption='[[7zjh]], [[Resolution|resolution]] 3.39&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7zjh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZJH FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zjh OCA], [https://pdbe.org/7zjh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zjh RCSB], [https://www.ebi.ac.uk/pdbsum/7zjh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zjh ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A0G2JSH6_RAT A0A0G2JSH6_RAT]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+TRPV2 is a ligand-operated temperature sensor with poorly defined pharmacology. Here, we combine calcium imaging and patch-clamp electrophysiology with cryo-electron microscopy (cryo-EM) to explore how TRPV2 activity is modulated by the phytocannabinoid Delta(9)-tetrahydrocannabiorcol (C16) and by probenecid. C16 and probenecid act in concert to stimulate TRPV2 responses including histamine release from rat and human mast cells. Each ligand causes distinct conformational changes in TRPV2 as revealed by cryo-EM. Although the binding for probenecid remains elusive, C16 associates within the vanilloid pocket. As such, the C16 binding location is distinct from that of cannabidiol, partially overlapping with the binding site of the TRPV2 inhibitor piperlongumine. Taken together, we discover a new cannabinoid binding site in TRPV2 that is under the influence of allosteric control by probenecid. This molecular insight into ligand modulation enhances our understanding of TRPV2 in normal and pathophysiology.
-Authors:
+Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function.,Zhang L, Simonsen C, Zimova L, Wang K, Moparthi L, Gaudet R, Ekoff M, Nilsson G, Hellmich UA, Vlachova V, Gourdon P, Zygmunt PM Nat Commun. 2022 Dec 5;13(1):7483. doi: 10.1038/s41467-022-35163-y. PMID:36470868<ref>PMID:36470868</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 7zjh" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Rattus norvegicus]]
+[[Category: Gourdon P]]
+[[Category: Zhang L]]
+[[Category: Zygmunt PM]]