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==== | ==ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing GGACCC (Oligo 21)== | ||
<StructureSection load='7n5u' size='340' side='right'caption='[[7n5u]]' scene=''> | <StructureSection load='7n5u' size='340' side='right'caption='[[7n5u]], [[Resolution|resolution]] 2.86Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7n5u]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N5U FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n5u OCA], [https://pdbe.org/7n5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n5u RCSB], [https://www.ebi.ac.uk/pdbsum/7n5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n5u ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n5u OCA], [https://pdbe.org/7n5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n5u RCSB], [https://www.ebi.ac.uk/pdbsum/7n5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n5u ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/ZBT7A_HUMAN ZBT7A_HUMAN]] Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity). | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Cheng X]] | ||
[[Category: Horton JR]] | |||
[[Category: Ren R]] | |||
Revision as of 19:47, 7 September 2022
ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing GGACCC (Oligo 21)ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing GGACCC (Oligo 21)
Structural highlights
Function[ZBT7A_HUMAN] Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity). |
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