7xng: Difference between revisions

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-'''Unreleased structure'''
-The entry 7xng is ON HOLD  until May 26 2023
+==Crystal structure of CBP bromodomain liganded with Y08092(31g)==
+<StructureSection load='7xng' size='340' side='right'caption='[[7xng]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7xng]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XNG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XNG FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GI5:3-[(1-ethanoylindol-3-yl)carbonylamino]-5-[[(2S)-oxan-2-yl]oxymethyl]benzoic+acid'>GI5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xng OCA], [https://pdbe.org/7xng PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xng RCSB], [https://www.ebi.ac.uk/pdbsum/7xng PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xng ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.  Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[https://omim.org/entry/180849 180849]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>
-Authors: Xiang, Q., Zhang, Y., Wang, C., Song, M., Xu, Y.
+==See Also==
+*[[CREB-binding protein 3D structures|CREB-binding protein 3D structures]]
-Description: Crystal structure of CBP bromodomain liganded with Y08092(31g)
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Xiang, Q]]
+__TOC__
-[[Category: Xu, Y]]
+</StructureSection>
-[[Category: Zhang, Y]]
+[[Category: Homo sapiens]]
-[[Category: Wang, C]]
+[[Category: Large Structures]]
-[[Category: Song, M]]
+[[Category: Song M]]
+[[Category: Wang C]]
+[[Category: Xiang Q]]
+[[Category: Xu Y]]
+[[Category: Zhang Y]]