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==Structure of the Fibrinogen C-terminal domain of FGL1==
==Structure of human Fibrinogen-like protein 1==
<StructureSection load='7tz2' size='340' side='right'caption='[[7tz2]]' scene=''>
<StructureSection load='7tz2' size='340' side='right'caption='[[7tz2]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TZ2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[7tz2]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TZ2 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tz2 OCA], [https://pdbe.org/7tz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tz2 RCSB], [https://www.ebi.ac.uk/pdbsum/7tz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tz2 ProSAT]</span></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tz2 OCA], [https://pdbe.org/7tz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tz2 RCSB], [https://www.ebi.ac.uk/pdbsum/7tz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tz2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/FGL1_HUMAN FGL1_HUMAN]] Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966). Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967).<ref>PMID:11470158</ref> <ref>PMID:19880967</ref> <ref>PMID:30580966</ref> 
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Luca VC]]
[[Category: Luca, V C]]
[[Category: Ming Q]]
[[Category: Ming, Q]]
[[Category: Tran TH]]
[[Category: Tran, T H]]
[[Category: Fibrinogen-like domain]]
[[Category: Immune suppression]]
[[Category: Immunosuppressant]]
[[Category: Oligomerization]]
[[Category: Secretion]]

Revision as of 13:27, 18 May 2022

Structure of human Fibrinogen-like protein 1Structure of human Fibrinogen-like protein 1

Structural highlights

7tz2 is a 3 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[FGL1_HUMAN] Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966). Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967).[1] [2] [3]

References

  1. ↑ Hara H, Yoshimura H, Uchida S, Toyoda Y, Aoki M, Sakai Y, Morimoto S, Shiokawa K. Molecular cloning and functional expression analysis of a cDNA for human hepassocin, a liver-specific protein with hepatocyte mitogenic activity. Biochim Biophys Acta. 2001 Jul 30;1520(1):45-53. PMID:11470158
  2. ↑ Li CY, Cao CZ, Xu WX, Cao MM, Yang F, Dong L, Yu M, Zhan YQ, Gao YB, Li W, Wang ZD, Ge CH, Wang QM, Peng RY, Yang XM. Recombinant human hepassocin stimulates proliferation of hepatocytes in vivo and improves survival in rats with fulminant hepatic failure. Gut. 2010 Jun;59(6):817-26. doi: 10.1136/gut.2008.171124. Epub 2009 Nov 1. PMID:19880967 doi:http://dx.doi.org/10.1136/gut.2008.171124
  3. ↑ Wang J, Sanmamed MF, Datar I, Su TT, Ji L, Sun J, Chen L, Chen Y, Zhu G, Yin W, Zheng L, Zhou T, Badri T, Yao S, Zhu S, Boto A, Sznol M, Melero I, Vignali DAA, Schalper K, Chen L. Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3. Cell. 2019 Jan 10;176(1-2):334-347.e12. doi: 10.1016/j.cell.2018.11.010. Epub, 2018 Dec 20. PMID:30580966 doi:http://dx.doi.org/10.1016/j.cell.2018.11.010

7tz2, resolution 2.55Å

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