Ribonucleotide Reductase: Difference between revisions
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== Ribonucleotide Reductase == | == Ribonucleotide Reductase == | ||
<StructureSection load=' | <StructureSection load='1rlr' size='340' side='right' caption='Ribonucleotide Reductase (PDB code [[1rlr]])' scene=''> | ||
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== Introduction == | == Introduction == | ||
Ribonucleotide reductase, <scene name='91/910568/1rlr_1/1'>RNR</scene>, is one of the major enzymes that aids in the synthesis of deoxyribonucleotides. These precursors of DNA are vital for DNA synthesis, so RNRs are required in all living cells to replicate and repair DNA. The reaction catalyzed through RNR is the only biochemical pathway that can synthesize new deoxyribonucleotide triphosphates (dNTPs).<ref name="intro">DOI:10.3389/fcimb.2014.00052</ref> This enzyme has led to and contributed to the evolution of genetic material that exists today. RNR consists of three different classes: I, II, and III. The classes differ in which they require different metal cofactors in order to initiate the reaction. This then leads to different environmental factors affecting the enzyme and its different classes. | '''Ribonucleotide reductase''', <scene name='91/910568/1rlr_1/1'>RNR</scene>, is one of the major enzymes that aids in the synthesis of deoxyribonucleotides. These precursors of DNA are vital for DNA synthesis, so RNRs are required in all living cells to replicate and repair DNA. The reaction catalyzed through RNR is the only biochemical pathway that can synthesize new deoxyribonucleotide triphosphates (dNTPs).<ref name="intro">DOI:10.3389/fcimb.2014.00052</ref> This enzyme has led to and contributed to the evolution of genetic material that exists today. RNR consists of three different classes: I, II, and III. The classes differ in which they require different metal cofactors in order to initiate the reaction. This then leads to different environmental factors affecting the enzyme and its different classes. | ||
== Structure == | == Structure == | ||