2yh0: Difference between revisions

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OCA

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 ==Solution structure of the closed conformation of human U2AF65 tandem RRM1 and RRM2 domains==
-<StructureSection load='2yh0' size='340' side='right'caption='[[2yh0]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+<StructureSection load='2yh0' size='340' side='right'caption='[[2yh0]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2yh0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YH0 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2yh0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YH0 FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2u2f|2u2f]], [[1u2f|1u2f]], [[1opi|1opi]], [[1o0p|1o0p]], [[2g4b|2g4b]], [[1jmt|1jmt]], [[2yh4|2yh4]], [[2yh1|2yh1]]</div></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yh0 OCA], [https://pdbe.org/2yh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yh0 RCSB], [https://www.ebi.ac.uk/pdbsum/2yh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yh0 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/U2AF2_HUMAN U2AF2_HUMAN]] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:15009664</ref> <ref>PMID:19470458</ref> <ref>PMID:19574390</ref>
+[https://www.uniprot.org/uniprot/U2AF2_HUMAN U2AF2_HUMAN] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:15009664</ref> <ref>PMID:19470458</ref> <ref>PMID:19574390</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 22: / Line 22: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Gasch, A]]
+[[Category: Gasch A]]
-[[Category: Mackereth, C D]]
+[[Category: Mackereth CD]]
-[[Category: Madl, T]]
+[[Category: Madl T]]
-[[Category: Sattler, M]]
+[[Category: Sattler M]]
-[[Category: Simon, B]]
+[[Category: Simon B]]
-[[Category: Zanier, K]]
+[[Category: Zanier K]]
-[[Category: Mrna processing]]
-[[Category: Pre-mrna splicing]]
-[[Category: Rna binding protein]]
-[[Category: Transcription]]