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==== | ==cryo-EM structure of H2BK34ub nucleosome== | ||
<StructureSection load='7xd0' size='340' side='right'caption='[[7xd0]]' scene=''> | <StructureSection load='7xd0' size='340' side='right'caption='[[7xd0]], [[Resolution|resolution]] 3.48Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7xd0]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XD0 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xd0 OCA], [https://pdbe.org/7xd0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xd0 RCSB], [https://www.ebi.ac.uk/pdbsum/7xd0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xd0 ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xd0 OCA], [https://pdbe.org/7xd0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xd0 RCSB], [https://www.ebi.ac.uk/pdbsum/7xd0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xd0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/A0A672PXK1_SINGR A0A672PXK1_SINGR]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.[ARBA:ARBA00002001][RuleBase:RU000528] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Synthetic construct]] | ||
[[Category: Ai HS]] | |||
[[Category: Liu AJ]] | |||
[[Category: Liu L]] | |||
[[Category: Lou ZY]] | |||
Revision as of 19:50, 7 September 2022
cryo-EM structure of H2BK34ub nucleosomecryo-EM structure of H2BK34ub nucleosome
Structural highlights
Function[A0A672PXK1_SINGR] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.[ARBA:ARBA00002001][RuleBase:RU000528] |
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