7x3l: Difference between revisions
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==Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07044== | |||
<StructureSection load='7x3l' size='340' side='right'caption='[[7x3l]], [[Resolution|resolution]] 1.86Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7x3l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X3L FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8FO:(2~{R})-2-[4-(3-fluoranyl-4-methyl-phenyl)-3-(trifluoromethyl)phenyl]butanoic+acid'>8FO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x3l OCA], [https://pdbe.org/7x3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x3l RCSB], [https://www.ebi.ac.uk/pdbsum/7x3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x3l ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Liu | [[Category: Chen Y]] | ||
[[Category: | [[Category: Chu X]] | ||
[[Category: | [[Category: Fang P]] | ||
[[Category: | [[Category: Feng F]] | ||
[[Category: | [[Category: Guo Q]] | ||
[[Category: He S]] | |||
[[Category: Jiang J]] | |||
[[Category: Liu W]] | |||
[[Category: Liu Y]] | |||
[[Category: Sun H]] | |||
[[Category: Zhang X]] | |||
[[Category: Zhao L]] | |||
Revision as of 10:27, 8 March 2023
Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07044Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07044
Structural highlights
FunctionAK1C3_HUMAN Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. |
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