Sandbox Reserved 1726: Difference between revisions
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{{Template:CH462_Biochemistry_II_2022}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Template:CH462_Biochemistry_II_2022}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
==Anaplastic Lymphoma Kinase Extracellular Region== | ==Anaplastic Lymphoma Kinase Extracellular Region== | ||
<StructureSection load='7N00' size=' | <StructureSection load='7N00' size='500' side='right' caption=' Structure of Anaplastic Lymphoma Kinase [https://www.rcsb.org/structure/7N00 7N00]' scene='90/904331/Alk_full/1'> | ||
== Background == | == Background == | ||
Anaplastic Lymphoma Kinase (ALK) is a [https://en.wikipedia.org/wiki/Transmembrane_protein transmembrane] receptor and a member of the family of [https://proteopedia.org/wiki/index.php/Receptor_tyrosine_kinases Receptor Tyrosine Kinases (RTKs)], a family of biomolecules that are primarily responsible for biosignaling pathways such as the insulin signaling pathway. It was discovered as a novel tyrosine phosphoprotein in 1994 in an analysis of [https://lymphoma.org/aboutlymphoma/nhl/alcl/ Anaplastic Large-Cell Lymphoma], the protein's namesake. A full analysis and characterization of ALK was completed in 1997, properly identifying it as a RTK, and linking it closely to [https://en.wikipedia.org/wiki/Leukocyte_receptor_tyrosine_kinase Leukocyte Tyrosine Kinase] (LTK). | Anaplastic Lymphoma Kinase (ALK) is a [https://en.wikipedia.org/wiki/Transmembrane_protein transmembrane] receptor and a member of the family of [https://proteopedia.org/wiki/index.php/Receptor_tyrosine_kinases Receptor Tyrosine Kinases (RTKs)], a family of biomolecules that are primarily responsible for biosignaling pathways such as the insulin signaling pathway. It was discovered as a novel tyrosine phosphoprotein in 1994 in an analysis of [https://lymphoma.org/aboutlymphoma/nhl/alcl/ Anaplastic Large-Cell Lymphoma], the protein's namesake. A full analysis and characterization of ALK was completed in 1997, properly identifying it as a RTK, and linking it closely to [https://en.wikipedia.org/wiki/Leukocyte_receptor_tyrosine_kinase Leukocyte Tyrosine Kinase] (LTK). | ||