1gtt: Difference between revisions

Revision as of 06:04, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1gtt.png

Template:STRUCTURE 1gtt

CRYSTAL STRUCTURE OF HPCECRYSTAL STRUCTURE OF HPCE

Template:ABSTRACT PUBMED 11863436

About this StructureAbout this Structure

1GTT is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

The crystal structure of HpcE, a bifunctional decarboxylase/isomerase with a multifunctional fold., Tame JR, Namba K, Dodson EJ, Roper DI, Biochemistry. 2002 Mar 5;41(9):2982-9. PMID:11863436

Page seeded by OCA on Tue Jul 1 06:04:07 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''CRYSTAL STRUCTURE OF HPCE'''
+===CRYSTAL STRUCTURE OF HPCE===
-==Overview==
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-The structure of the bifunctional enzyme HpcE (OPET decarboxylase/HHDD isomerase) from Escherichia coli shows that the protein consists of highly similar N and C terminal halves. Sequence matches suggest that this fold is widespread among different species, including man. Many of these homologues are uncharacterized but apparently connected with the metabolism of aromatic compounds. The domain shows similar topology to the C terminal domain of fumarylacetoacetate hydrolase (FAH), a functionally related enzyme, despite lacking significant overall sequence similarity. HpcE is known to catalyze two rather different reactions, and comparisons with FAH allow some tentative conclusions to be drawn about the active sites. Key mutations within the active site apparently allow enzymes with this fold to carry out a variety chemical processes.
+The line below this paragraph, {{ABSTRACT_PUBMED_11863436}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11863436 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_11863436}}
 ==About this Structure==
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 [[Category: Isomerase]]
 [[Category: Lyase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 18:00:00 2008''
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