2wj1: Difference between revisions
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<StructureSection load='2wj1' size='340' side='right'caption='[[2wj1]], [[Resolution|resolution]] 1.84Å' scene=''> | <StructureSection load='2wj1' size='340' side='right'caption='[[2wj1]], [[Resolution|resolution]] 1.84Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wj1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2wj1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WJ1 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=S99:7-PHENYL-1-(4-PYRIDIN-2-YL-1,3-OXAZOL-2-YL)HEPTANE-1,1-DIOL'>S99</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wj1 OCA], [https://pdbe.org/2wj1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wj1 RCSB], [https://www.ebi.ac.uk/pdbsum/2wj1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wj1 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wj1 OCA], [https://pdbe.org/2wj1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wj1 RCSB], [https://www.ebi.ac.uk/pdbsum/2wj1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wj1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Boger | [[Category: Rattus norvegicus]] | ||
[[Category: Cravatt | [[Category: Boger DL]] | ||
[[Category: DeMartino | [[Category: Cravatt BF]] | ||
[[Category: Garfunkle | [[Category: DeMartino JK]] | ||
[[Category: Mileni | [[Category: Garfunkle J]] | ||
[[Category: Stevens | [[Category: Mileni M]] | ||
[[Category: Stevens RC]] | |||