Methionine synthase: Difference between revisions
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<StructureSection load='1k7y' size='310' side='right' caption='B-12 dependent fragment of E. coli methionine synthase with Cobalamin (in pink)' scene=''> | <StructureSection load='1k7y' size='310' side='right' caption='B-12 dependent fragment of E. coli methionine synthase with Cobalamin (in pink)' scene=''> | ||
This page is being worked on during the Spring 2022 semester. | This page is being worked on during the Spring 2022 semester. | ||
Methionine is an essential amino acid required in order for our bodies to have healthy cell and tissue growth. Unfortunately, it is not naturally derived and is dependent on our diet. Methionine synthase methylates homocysteine, another amino acid obtained typically by meat we consume, to methionine. The change from homocysteine to methionine is one methyl group, by which is received from methyltetrahydrofolate (MTHF), a product of Methylenetetrahydrofolate reductase (MTHFR), as the methyl donor and a protein-bound B-12 vitamin Cobalamin as the methyl carrier <ref>DOI: 10.1038/nature10916</ref>. | |||
EC: 2.1.1.13 | EC: 2.1.1.13 | ||
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</StructureSection> | </StructureSection> | ||
[[Image:MetHsynthase.jpeg]] | [[Image:MetHsynthase.jpeg]] | ||
== Vitamin B-12 == | == Vitamin B-12 == | ||