7u2k: Difference between revisions

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'''Unreleased structure'''


The entry 7u2k is ON HOLD  until Paper Publication
==C6-guano bound Mu Opioid Receptor-Gi Protein Complex==
 
<StructureSection load='7u2k' size='340' side='right'caption='[[7u2k]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
Authors: Wang, H., Kobilka, B.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7u2k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U2K FirstGlance]. <br>
Description: C6-guano bound Mu Opioid Receptor-Gi Protein Complex
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KZR:N-(6-carbamimidamidohexyl)-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide'>KZR</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u2k OCA], [https://pdbe.org/7u2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u2k RCSB], [https://www.ebi.ac.uk/pdbsum/7u2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u2k ProSAT]</span></td></tr>
[[Category: Wang, H]]
</table>
[[Category: Kobilka, B]]
== Function ==
[https://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Kobilka B]]
[[Category: Wang H]]

Latest revision as of 11:12, 7 December 2022

C6-guano bound Mu Opioid Receptor-Gi Protein ComplexC6-guano bound Mu Opioid Receptor-Gi Protein Complex

Structural highlights

7u2k is a 4 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GBB1_HUMAN Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.[1]

References

  1. ↑ Johnston CA, Kimple AJ, Giguere PM, Siderovski DP. Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2. Structure. 2008 Jul;16(7):1086-94. PMID:18611381 doi:http://dx.doi.org/10.1016/j.str.2008.04.010

7u2k, resolution 3.30Å

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OCA
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