Sandbox Reserved 1713: Difference between revisions
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=Anaplastic Lymphoma Kinase= | =Anaplastic Lymphoma Kinase= | ||
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
<StructureSection load='7n00' size='350' frame='true'side='right' caption='Anaplastic Lymphoma Kinase' scene=’’> | |||
Anaplastic Lymphoma Kinase is a receptor tyrosine [https://pubmed.ncbi.nlm.nih.gov/32114309/ kinase]. ALK transfers a phosphate group from [https://www.ncbi.nlm.nih.gov/books/NBK553175/ ATP] to a tyrosine residue on an enzyme which activates a signaling cascade, and ALK becomes activated when a ligand called [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789956/ ALKAL] binds to the binding surface on an extracellular domain of ALK. ALK is an integral membrane protein. | |||
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
The active state of the kinase is when two monomers have completed a conformational change and moved across the membrane to form a <scene name='90/904317/Dimer_full_colored/3'>dimer</scene>. | |||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||