2uw2: Difference between revisions

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 <StructureSection load='2uw2' size='340' side='right'caption='[[2uw2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2uw2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2iyh 2iyh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UW2 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2uw2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2iyh 2iyh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UW2 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2iyh|2iyh]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uw2 OCA], [https://pdbe.org/2uw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uw2 RCSB], [https://www.ebi.ac.uk/pdbsum/2uw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uw2 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/RIR2_HUMAN RIR2_HUMAN] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 24: / Line 25: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Ribonucleoside-diphosphate reductase]]
+[[Category: Arrowsmith C]]
-[[Category: Arrowsmith, C]]
+[[Category: Berglund H]]
-[[Category: Berg, S Van Den]]
+[[Category: Busam R]]
-[[Category: Berglund, H]]
+[[Category: Collins R]]
-[[Category: Busam, R]]
+[[Category: Edwards A]]
-[[Category: Collins, R]]
+[[Category: Ehn M]]
-[[Category: Edwards, A]]
+[[Category: Flodin S]]
-[[Category: Ehn, M]]
+[[Category: Flores A]]
-[[Category: Flodin, S]]
+[[Category: Graslund S]]
-[[Category: Flores, A]]
+[[Category: Hallberg BM]]
-[[Category: Graslund, S]]
+[[Category: Hammarstrom M]]
-[[Category: Hallberg, B M]]
+[[Category: Hogbom M]]
-[[Category: Hammarstrom, M]]
+[[Category: Holmberg Schiavone L]]
-[[Category: Hogbom, M]]
+[[Category: Kotenyova T]]
-[[Category: Kotenyova, T]]
+[[Category: Magnusdottir A]]
-[[Category: Magnusdottir, A]]
+[[Category: Moche M]]
-[[Category: Moche, M]]
+[[Category: Nilsson-Ehle P]]
-[[Category: Nilsson-Ehle, P]]
+[[Category: Nordlund P]]
-[[Category: Nordlund, P]]
+[[Category: Nyman T]]
-[[Category: Nyman, T]]
+[[Category: Ogg D]]
-[[Category: Ogg, D]]
+[[Category: Persson C]]
-[[Category: Persson, C]]
+[[Category: Sagemark J]]
-[[Category: Sagemark, J]]
+[[Category: Stenmark P]]
-[[Category: Schiavone, L Holmberg]]
+[[Category: Sundstrom M]]
-[[Category: Stenmark, P]]
+[[Category: Thorsell AG]]
-[[Category: Sundstrom, M]]
+[[Category: Uppenberg J]]
-[[Category: Thorsell, A G]]
+[[Category: Van Den Berg S]]
-[[Category: Uppenberg, J]]
+[[Category: Wallden K]]
-[[Category: Wallden, K]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J]]
+[[Category: Welin M]]
-[[Category: Welin, M]]
-[[Category: Diiron]]
-[[Category: Dna replication]]
-[[Category: Iron]]
-[[Category: Metal-binding]]
-[[Category: Oxidoreductase]]
-[[Category: Phosphorylation]]
-[[Category: R2]]
-[[Category: R2 subunit]]
-[[Category: Radical]]
-[[Category: Ribonucleotide reductase]]
-[[Category: Small subunit ribonucleotide reductase]]