1gp2: Difference between revisions

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-[[Image:1gp2.gif|left|200px]]
+{{Seed}}
+[[Image:1gp2.png|left|200px]]
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 {{STRUCTURE_1gp2|  PDB=1gp2  |  SCENE=  }}
-'''G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND'''
+===G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND===
-==Overview==
+<!--
-The crystallographic structure of the G protein heterotrimer Gi alpha 1(GDP)beta 1 gamma 2 (at 2.3 A) reveals two nonoverlapping regions of contact between alpha and beta, an extended interface between beta and nearly all of gamma, and limited interaction of alpha with gamma. The major alpha/beta interface covers switch II of alpha, and GTP-induced rearrangement of switch II causes subunit dissociation during signaling. Alterations in GDP binding in the heterotrimer (compared with alpha-GDP) explain stabilization of the inactive conformation of alpha by beta gamma. Repeated WD motifs in beta form a circularized sevenfold beta propeller. The conserved cores of these motifs are a scaffold for display of their more variable linkers on the exterior face of each propeller blade.
+The line below this paragraph, {{ABSTRACT_PUBMED_8521505}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8521505 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8521505}}
 ==About this Structure==
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 [[Category: Signal transduction protein]]
 [[Category: Wd40]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 17:50:33 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 05:37:42 2008''