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==Recognition and targeting mechanisms by chaperones in flagella assembly and operation==
==Recognition and targeting mechanisms by chaperones in flagella assembly and operation==
<StructureSection load='5kp0' size='340' side='right'caption='[[5kp0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='5kp0' size='340' side='right'caption='[[5kp0]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5kp0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salty Salty]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KP0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5kp0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KP0 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fliT, STM1962, fliI, fla AIII, flaC, STM1972 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kp0 OCA], [https://pdbe.org/5kp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kp0 RCSB], [https://www.ebi.ac.uk/pdbsum/5kp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kp0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kp0 OCA], [https://pdbe.org/5kp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kp0 RCSB], [https://www.ebi.ac.uk/pdbsum/5kp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kp0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/FLIT_SALTY FLIT_SALTY]] Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.<ref>PMID:10320579</ref> <ref>PMID:10791024</ref> <ref>PMID:11169117</ref> <ref>PMID:16952964</ref>
[https://www.uniprot.org/uniprot/FLIT_SALTY FLIT_SALTY] Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.<ref>PMID:10320579</ref> <ref>PMID:10791024</ref> <ref>PMID:11169117</ref> <ref>PMID:16952964</ref> [https://www.uniprot.org/uniprot/FLII_SALTY FLII_SALTY] Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5kp0" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5kp0" style="background-color:#fffaf0;"></div>
==See Also==
*[[Flagellar protein 3D structures|Flagellar protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Salty]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
[[Category: Economou, A]]
[[Category: Economou A]]
[[Category: Kalodimos, C G]]
[[Category: Kalodimos CG]]
[[Category: Khanra, N K]]
[[Category: Khanra NK]]
[[Category: Rossi, P]]
[[Category: Rossi P]]
[[Category: Assembly factor]]
[[Category: Chaperone]]
[[Category: Flagella]]

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