Ribosome inactivating protein: Difference between revisions
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<StructureSection load='' size='350' side='right' caption='Ribosome inactivating protein from pokeweed complex with adenine (PDB code [[1qci]])' scene='70/706276/Cv/1'> | <StructureSection load='' size='350' side='right' caption='Ribosome inactivating protein from pokeweed complex with adenine (PDB code [[1qci]])' scene='70/706276/Cv/1'> | ||
== Function == | == Function == | ||
'''Ribosome inactivating protein''' (RIP) is a bacterial or plant toxin which inhibits protein synthesis. RIP inactivates the ribosomal 60S subunit by N-glycosidic cleavage which results in releasing a specific adenine from 28S rRNA<ref>PMID:3510899</ref>. '''Type 1 RIP''' have a single chain, while '''type 2 RIP''' (i.e., ricin, ebulin and nigrin) have two chains. '''Momorcharin''' is a RIP isolated from several plants<ref>PMID:23777339</ref>. | '''Ribosome inactivating protein''' (RIP) is a bacterial or plant toxin which inhibits protein synthesis. RIP inactivates the ribosomal 60S subunit by N-glycosidic cleavage which results in releasing a specific adenine from 28S rRNA<ref>PMID:3510899</ref>. '''Type 1 RIP''' have a single chain, while '''type 2 RIP''' (i.e., ricin, ebulin and nigrin) have two chains. '''Momorcharin''' is a RIP isolated from several plants<ref>PMID:23777339</ref>. '''Trichosanthin''' is a RIP isolated from snake gourd<ref>PMID:15804517</ref>. | ||
== Relevance == | == Relevance == | ||