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==Solution Structure of the Pleckstrin Homology Domain of Mouse Ethanol Decreased 4 Protein== | ==Solution Structure of the Pleckstrin Homology Domain of Mouse Ethanol Decreased 4 Protein== | ||
<StructureSection load='1wgq' size='340' side='right'caption='[[1wgq | <StructureSection load='1wgq' size='340' side='right'caption='[[1wgq]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1wgq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1wgq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WGQ FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wgq OCA], [https://pdbe.org/1wgq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wgq RCSB], [https://www.ebi.ac.uk/pdbsum/1wgq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wgq ProSAT], [https://www.topsan.org/Proteins/RSGI/1wgq TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wgq OCA], [https://pdbe.org/1wgq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wgq RCSB], [https://www.ebi.ac.uk/pdbsum/1wgq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wgq ProSAT], [https://www.topsan.org/Proteins/RSGI/1wgq TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/FGD6_MOUSE FGD6_MOUSE] May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Inoue | [[Category: Inoue M]] | ||
[[Category: Kigawa | [[Category: Kigawa T]] | ||
[[Category: Koshiba | [[Category: Koshiba S]] | ||
[[Category: Li | [[Category: Li H]] | ||
[[Category: Yokoyama S]] | |||
[[Category: Yokoyama | |||
Latest revision as of 16:38, 9 May 2024
Solution Structure of the Pleckstrin Homology Domain of Mouse Ethanol Decreased 4 ProteinSolution Structure of the Pleckstrin Homology Domain of Mouse Ethanol Decreased 4 Protein
Structural highlights
FunctionFGD6_MOUSE May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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