2n7q: Difference between revisions

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==Structure of the transmembrane domain of human nicastrin in SDS micelles==
==Structure of the transmembrane domain of human nicastrin in SDS micelles==
<StructureSection load='2n7q' size='340' side='right'caption='[[2n7q]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2n7q' size='340' side='right'caption='[[2n7q]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2n7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N7Q FirstGlance]. <br>
<table><tr><td colspan='2'>[[2n7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N7Q FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2n7r|2n7r]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7q OCA], [https://pdbe.org/2n7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n7q RCSB], [https://www.ebi.ac.uk/pdbsum/2n7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7q ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7q OCA], [https://pdbe.org/2n7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n7q RCSB], [https://www.ebi.ac.uk/pdbsum/2n7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7q ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN]] Hidradenitis suppurativa. The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Hidradenitis suppurativa. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN]] Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.  
[https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Kang, C]]
[[Category: Kang C]]
[[Category: Li, Q]]
[[Category: Li Q]]
[[Category: Li, Y]]
[[Category: Li Y]]
[[Category: Liew, L]]
[[Category: Liew L]]
[[Category: Detergent micelle]]
[[Category: Gamma-secretase]]
[[Category: Membrane protein]]
[[Category: Nicastrin]]

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