7yx6: Difference between revisions
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==Crystal structure of YTHDF2 with compound YLI_DF_027== | ==Crystal structure of YTHDF2 with compound YLI_DF_027== | ||
<StructureSection load='7yx6' size='340' side='right'caption='[[7yx6]]' scene=''> | <StructureSection load='7yx6' size='340' side='right'caption='[[7yx6]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YX6 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7yx6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YX6 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yx6 OCA], [https://pdbe.org/7yx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yx6 RCSB], [https://www.ebi.ac.uk/pdbsum/7yx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yx6 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=I6R:6-ethyl-5~{H}-pyrimidine-2,4-dione'>I6R</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yx6 OCA], [https://pdbe.org/7yx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yx6 RCSB], [https://www.ebi.ac.uk/pdbsum/7yx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yx6 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/YTHD2_HUMAN YTHD2_HUMAN]] Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization of to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation.<ref>PMID:22575960</ref> <ref>PMID:24284625</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Caflisch A]] | [[Category: Caflisch, A]] | ||
[[Category: Li Y]] | [[Category: Li, Y]] | ||
[[Category: Nai F]] | [[Category: Nai, F]] | ||
[[Category: Epitranscriptomic reader]] | |||
[[Category: M6a reader]] | |||
[[Category: Rna binding protein]] | |||
Revision as of 10:27, 16 March 2022
Crystal structure of YTHDF2 with compound YLI_DF_027Crystal structure of YTHDF2 with compound YLI_DF_027
Structural highlights
Function[YTHD2_HUMAN] Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization of to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation.[1] [2] References
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