1emx: Difference between revisions

No edit summary
No edit summary
Line 1: Line 1:


==SOLUTION STRUCTURE OF HPTX2, A TOXIN FROM HETEROPODA VENATORIA SPIDER VENOM THAT BLOCKS KV4.2 POTASSIUM CHANNEL==
==SOLUTION STRUCTURE OF HPTX2, A TOXIN FROM HETEROPODA VENATORIA SPIDER VENOM THAT BLOCKS KV4.2 POTASSIUM CHANNEL==
<StructureSection load='1emx' size='340' side='right'caption='[[1emx]], [[NMR_Ensembles_of_Models | 26 NMR models]]' scene=''>
<StructureSection load='1emx' size='340' side='right'caption='[[1emx]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1emx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aranea_venatoria Aranea venatoria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EMX FirstGlance]. <br>
<table><tr><td colspan='2'>[[1emx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Heteropoda_venatoria Heteropoda venatoria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EMX FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1emx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1emx OCA], [https://pdbe.org/1emx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1emx RCSB], [https://www.ebi.ac.uk/pdbsum/1emx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1emx ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1emx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1emx OCA], [https://pdbe.org/1emx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1emx RCSB], [https://www.ebi.ac.uk/pdbsum/1emx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1emx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TXHP2_HETVE TXHP2_HETVE]] Inhibitor of voltage-gated potassium channels of the Kv4/KCND family. Inhibition of Kv4.3/KCND3 and Kv4.2/KCND2 is strongly voltage-dependent, while inhibition of Kv4.1/KCND1 shows less voltage-dependence. Its binding site may be near the potassium channel voltage sensor. Also blocks calcium channels.<ref>PMID:9058605</ref> [REFERENCE:2]<ref>PMID:15733564</ref>
[https://www.uniprot.org/uniprot/TXHP2_HETVE TXHP2_HETVE] Inhibitor of voltage-gated potassium channels of the Kv4/KCND family. Inhibition of Kv4.3/KCND3 and Kv4.2/KCND2 is strongly voltage-dependent, while inhibition of Kv4.1/KCND1 shows less voltage-dependence. Its binding site may be near the potassium channel voltage sensor. Also blocks calcium channels.<ref>PMID:9058605</ref> [REFERENCE:2]<ref>PMID:15733564</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 21: Line 22:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Aranea venatoria]]
[[Category: Heteropoda venatoria]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bernard, C]]
[[Category: Bernard C]]
[[Category: Bishoff, U]]
[[Category: Bishoff U]]
[[Category: Darbon, H]]
[[Category: Darbon H]]
[[Category: Ferrat, G]]
[[Category: Ferrat G]]
[[Category: Legros, C]]
[[Category: Legros C]]
[[Category: Marquardt, A]]
[[Category: Marquardt A]]
[[Category: Pongs, O]]
[[Category: Pongs O]]
[[Category: Toxin]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA