1cmz: Difference between revisions
No edit summary |
No edit summary |
||
Line 1: | Line 1: | ||
==SOLUTION STRUCTURE OF GAIP (GALPHA INTERACTING PROTEIN): A REGULATOR OF G PROTEIN SIGNALING== | ==SOLUTION STRUCTURE OF GAIP (GALPHA INTERACTING PROTEIN): A REGULATOR OF G PROTEIN SIGNALING== | ||
<StructureSection load='1cmz' size='340' side='right'caption='[[1cmz | <StructureSection load='1cmz' size='340' side='right'caption='[[1cmz]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1cmz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1cmz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CMZ FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cmz OCA], [https://pdbe.org/1cmz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cmz RCSB], [https://www.ebi.ac.uk/pdbsum/1cmz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cmz ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cmz OCA], [https://pdbe.org/1cmz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cmz RCSB], [https://www.ebi.ac.uk/pdbsum/1cmz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cmz ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/RGS19_HUMAN RGS19_HUMAN] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Line 31: | Line 32: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Alba | [[Category: De Alba E]] | ||
[[Category: De Vries L]] | |||
[[Category: Farquhar MG]] | |||
[[Category: Vries | [[Category: Tjandra N]] | ||
[[Category: | |||
[[Category: | |||