3dk8: Difference between revisions

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<StructureSection load='3dk8' size='340' side='right'caption='[[3dk8]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
<StructureSection load='3dk8' size='340' side='right'caption='[[3dk8]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3dk8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DK8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3dk8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DK8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3djg|3djg]], [[3djj|3djj]], [[3dk4|3dk4]], [[3dk9|3dk9]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GSR, GLUR, GRD1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutathione-disulfide_reductase Glutathione-disulfide reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.7 1.8.1.7] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dk8 OCA], [https://pdbe.org/3dk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dk8 RCSB], [https://www.ebi.ac.uk/pdbsum/3dk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dk8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dk8 OCA], [https://pdbe.org/3dk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dk8 RCSB], [https://www.ebi.ac.uk/pdbsum/3dk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dk8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/GSHR_HUMAN GSHR_HUMAN]] Maintains high levels of reduced glutathione in the cytosol.  
[https://www.uniprot.org/uniprot/GSHR_HUMAN GSHR_HUMAN] Maintains high levels of reduced glutathione in the cytosol.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Glutathione-disulfide reductase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Berkholz, D S]]
[[Category: Berkholz DS]]
[[Category: Faber, H R]]
[[Category: Faber HR]]
[[Category: Karplus, P A]]
[[Category: Karplus PA]]
[[Category: Savvides, S N]]
[[Category: Savvides SN]]
[[Category: Alternative initiation]]
[[Category: Fad]]
[[Category: Flavoenzyme]]
[[Category: Flavoprotein]]
[[Category: Glutathione]]
[[Category: Mitochondrion]]
[[Category: Nadp]]
[[Category: Nicotinamide]]
[[Category: Oxidoreductase]]
[[Category: Phosphoprotein]]
[[Category: Redox-active center]]
[[Category: Transit peptide]]

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