7to3: Difference between revisions

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-'''Unreleased structure'''
-The entry 7to3 is ON HOLD  until Paper Publication
+==Structure of Enterobacter cloacae Cap2-CdnD02 2:2 complex==
+<StructureSection load='7to3' size='340' side='right'caption='[[7to3]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7to3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterobacter_cloacae Enterobacter cloacae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TO3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TO3 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7to3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7to3 OCA], [https://pdbe.org/7to3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7to3 RCSB], [https://www.ebi.ac.uk/pdbsum/7to3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7to3 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CDND2_ENTCL CDND2_ENTCL] CBASS (cyclic oligonucleotide-based antiphage signaling system) provides immunity against bacteriophage. The CD-NTase protein synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals. The signals activate a diverse range of effectors, leading to bacterial cell death and thus abortive phage infection. A type II-C(AAG) CBASS system (PubMed:32839535).<ref>PMID:32544385</ref> <ref>PMID:32839535</ref>   Cyclic trinucleotide synthase that catalyzes the synthesis of 3',3',3'-cyclic AMP-AMP-GMP as the major product, a second messenger for cell signal transduction.<ref>PMID:30787435</ref>   Protects E.coli against phage T2 infection. When the cdnD-cap2-cap3-cap4 operon is introduced in E.coli there is a more than 10(3) decrease in the efficiency of T2 plaque formation. The operon does not protect against phage T5 and only about 10-fold against T7.<ref>PMID:32544385</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Enterobacter cloacae]]
+[[Category: Large Structures]]
+[[Category: Corbett KD]]
+[[Category: Gu Y]]
+[[Category: Lau RK]]
+[[Category: Ledvina HE]]
+[[Category: Quan Y]]
+[[Category: Whiteley AT]]
+[[Category: Ye Q]]
+[[Category: Zhou H]]