NADPH oxidase: Difference between revisions
Jump to navigation
Jump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
==Introduction== | ==Introduction== | ||
<StructureSection load='2dyb' size='340' side='right' caption=' | <StructureSection load='2dyb' size='340' side='right' caption='Human NADPH oxidase p40(phox) subunit complex with cysteine cacodylate (PDB code [[2dyb]])' scene=''> | ||
'''NADPH oxidase''' in its entirety leads to the release of reactive oxygen species; this process is called oxidative burst, where the eradication of invading microorganisms in macrophages and neutrophils ensues. NADPH oxidase is important in the maintenance of immune function, apoptosis, and cell growth. In previous times it was believed that NADPH oxidase generation of superoxides was only to happen in phagocytes, but inconsequent research studies, there are many enzymes that are responsible for reactive oxygen species production. For example, in kidneys, reactive oxygen species are produced from NOX3, and those molecules monitor renal function through sodium transport and oxygenation. Adding on, oxygen radicals increase sodium chloride absorption in the loop of Henle, which results in the regulation of sodium and hydrogen ion exchange. NADPH oxidase is known to function itself as a bacteria killer from the production of bacterial oxygen species by using oxygen and NADPH as substrates. In general, NADPH oxidase generates superoxides by moving electrons from NADPH inside of a cell and conjugating the oxygen atom to make superoxides | '''NADPH oxidase''' in its entirety leads to the release of reactive oxygen species; this process is called oxidative burst, where the eradication of invading microorganisms in macrophages and neutrophils ensues. NADPH oxidase is important in the maintenance of immune function, apoptosis, and cell growth. In previous times it was believed that NADPH oxidase generation of superoxides was only to happen in phagocytes, but inconsequent research studies, there are many enzymes that are responsible for reactive oxygen species production. For example, in kidneys, reactive oxygen species are produced from NOX3, and those molecules monitor renal function through sodium transport and oxygenation. Adding on, oxygen radicals increase sodium chloride absorption in the loop of Henle, which results in the regulation of sodium and hydrogen ion exchange. NADPH oxidase is known to function itself as a bacteria killer from the production of bacterial oxygen species by using oxygen and NADPH as substrates. In general, NADPH oxidase generates superoxides by moving electrons from NADPH inside of a cell and conjugating the oxygen atom to make superoxides | ||
. | . | ||