3bab: Difference between revisions
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<StructureSection load='3bab' size='340' side='right'caption='[[3bab]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='3bab' size='340' side='right'caption='[[3bab]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3bab]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3bab]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BAB FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3BD:7-AMINO-2-TERT-BUTYL-4-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIDO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE'>3BD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3BD:7-AMINO-2-TERT-BUTYL-4-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIDO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE'>3BD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bab OCA], [https://pdbe.org/3bab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bab RCSB], [https://www.ebi.ac.uk/pdbsum/3bab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bab ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bab OCA], [https://pdbe.org/3bab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bab RCSB], [https://www.ebi.ac.uk/pdbsum/3bab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bab ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/DNLJ_ENTFA DNLJ_ENTFA] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Enterococcus | [[Category: Enterococcus faecalis]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Pinko | [[Category: Pinko C]] | ||
Latest revision as of 12:28, 21 February 2024
Structural Basis for the Inhibition of Bacterial NAD+ Dependent DNA LigaseStructural Basis for the Inhibition of Bacterial NAD+ Dependent DNA Ligase
Structural highlights
FunctionDNLJ_ENTFA DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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