1g1r: Difference between revisions

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-[[Image:1g1r.jpg|left|200px]]
+{{Seed}}
+[[Image:1g1r.png|left|200px]]
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 {{STRUCTURE_1g1r|  PDB=1g1r  |  SCENE=  }}
-'''Crystal structure of P-selectin lectin/EGF domains complexed with SLeX'''
+===Crystal structure of P-selectin lectin/EGF domains complexed with SLeX===
-==Overview==
+<!--
-P-, E- and L-selectin constitute a family of cell adhesion receptors that mediate the initial tethering and rolling of leukocytes on inflamed endothelium as a prelude to their firm attachment and extravasation into tissues. The selectins bind weakly to sialyl Lewisx (SLe(X))-like glycans, but with high-affinity to specific glycoprotein counterreceptors, including PSGL-1. Here, we report crystal structures of human P- and E-selectin constructs containing the lectin and EGF (LE) domains co-complexed with SLe(X). We also present the crystal structure of P-selectin LE co-complexed with the N-terminal domain of human PSGL-1 modified by both tyrosine sulfation and SLe(X). These structures reveal differences in how E- and P-selectin bind SLe(X) and the molecular basis of the high-affinity interaction between P-selectin and PSGL-1.
+The line below this paragraph, {{ABSTRACT_PUBMED_11081633}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11081633 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11081633}}
 ==About this Structure==
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 [[Category: Lectin]]
 [[Category: Slex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 17:01:40 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 04:16:34 2008''