1d5f: Difference between revisions
New page: left|200px<br /> <applet load="1d5f" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d5f, resolution 2.8Å" /> '''STRUCTURE OF AN E6AP... |
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[[Image:1d5f.gif|left|200px]]<br /> | [[Image:1d5f.gif|left|200px]]<br /><applet load="1d5f" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1d5f" size=" | |||
caption="1d5f, resolution 2.8Å" /> | caption="1d5f, resolution 2.8Å" /> | ||
'''STRUCTURE OF AN E6AP-UBCH7 COMPLEX: INSIGHTS INTO THE UBIQUITINATION PATHWAY'''<br /> | '''STRUCTURE OF AN E6AP-UBCH7 COMPLEX: INSIGHTS INTO THE UBIQUITINATION PATHWAY'''<br /> | ||
==Overview== | ==Overview== | ||
The E6AP ubiquitin-protein ligase (E3) mediates the human | The E6AP ubiquitin-protein ligase (E3) mediates the human papillomavirus-induced degradation of the p53 tumor suppressor in cervical cancer and is mutated in Angelman syndrome, a neurological disorder. The crystal structure of the catalytic hect domain of E6AP reveals a bilobal structure with a broad catalytic cleft at the junction of the two lobes. The cleft consists of conserved residues whose mutation interferes with ubiquitin-thioester bond formation and is the site of Angelman syndrome mutations. The crystal structure of the E6AP hect domain bound to the UbcH7 ubiquitin-conjugating enzyme (E2) reveals the determinants of E2-E3 specificity and provides insights into the transfer of ubiquitin from the E2 to the E3. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1D5F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1D5F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D5F OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Beaudenon, S.]] | [[Category: Beaudenon, S.]] | ||
[[Category: Howley, P | [[Category: Howley, P M.]] | ||
[[Category: Huang, L.]] | [[Category: Huang, L.]] | ||
[[Category: Huibregtse, J | [[Category: Huibregtse, J M.]] | ||
[[Category: Kinnucan, E.]] | [[Category: Kinnucan, E.]] | ||
[[Category: Pavletich, N | [[Category: Pavletich, N P.]] | ||
[[Category: Wang, G.]] | [[Category: Wang, G.]] | ||
[[Category: bilobal structure]] | [[Category: bilobal structure]] | ||
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[[Category: elongated shape]] | [[Category: elongated shape]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:13:18 2008'' | ||
