1g0u: Difference between revisions

Revision as of 04:14, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1g0u.png

Template:STRUCTURE 1g0u

A GATED CHANNEL INTO THE PROTEASOME CORE PARTICLEA GATED CHANNEL INTO THE PROTEASOME CORE PARTICLE

Template:ABSTRACT PUBMED 11062564

About this StructureAbout this Structure

1G0U is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

A gated channel into the proteasome core particle., Groll M, Bajorek M, Kohler A, Moroder L, Rubin DM, Huber R, Glickman MH, Finley D, Nat Struct Biol. 2000 Nov;7(11):1062-7. PMID:11062564

Page seeded by OCA on Tue Jul 1 04:14:02 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 {{STRUCTURE_1g0u|  PDB=1g0u  |  SCENE=  }}
-'''A GATED CHANNEL INTO THE PROTEASOME CORE PARTICLE'''
+===A GATED CHANNEL INTO THE PROTEASOME CORE PARTICLE===
-==Overview==
+<!--
-The core particle (CP) of the yeast proteasome is composed of four heptameric rings of subunits arranged in a hollow, barrel-like structure. We report that the CP is autoinhibited by the N-terminal tails of the outer (alpha) ring subunits. Crystallographic analysis showed that deletion of the tail of the alpha 3-subunit opens a channel into the proteolytically active interior chamber of the CP, thus derepressing peptide hydrolysis. In the latent state of the particle, the tails prevent substrate entry by imposing topological closure on the CP. Inhibition by the alpha-subunit tails is relieved upon binding of the regulatory particle to the CP to form the proteasome holoenzyme.
+The line below this paragraph, {{ABSTRACT_PUBMED_11062564}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11062564 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_11062564}}
 ==About this Structure==
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 [[Category: Proteasome]]
 [[Category: Ubiquitin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:59:23 2008''
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