1fzz: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:1fzz.gif|left|200px]]
+{{Seed}}
+[[Image:1fzz.png|left|200px]]
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 {{STRUCTURE_1fzz|  PDB=1fzz  |  SCENE=  }}
-'''THE CRYSTAL STRUCTURE OF THE COMPLEX OF NON-PEPTIDIC INHIBITOR ONO-6818 AND PORCINE PANCREATIC ELASTASE.'''
+===THE CRYSTAL STRUCTURE OF THE COMPLEX OF NON-PEPTIDIC INHIBITOR ONO-6818 AND PORCINE PANCREATIC ELASTASE.===
-==Overview==
+<!--
-The crystal structure of a new inhibitor of human neutrophil elastase (HNE), N-[2-[5-(tert-butyl)-1,3,4-oxadiazol-2-yl]-(IRS)-1-(methylethyl)-2-oxoethy l]-2-(5-amino-6-oxo-2-phenyl-6H-pyrimidin-1-ly)acetamide (ONO-6818, 1) complexed to porcine pancreatic elastase (PPE) has been determined at 1.86 A resolution. Analytical results provided evidence of a 1:1 complex in which the electrophilic ketone of 1 covalently bound to O gamma of Ser195 at the active site of PPE. The role of the unique electron-withdrawing ketone of 1 has been elucidated.
+The line below this paragraph, {{ABSTRACT_PUBMED_11310599}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11310599 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11310599}}
 ==About this Structure==
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 [[Category: Toda, M.]]
 [[Category: Enzyme-inhibitor complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:57:31 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 04:11:41 2008''