3afc: Difference between revisions
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<StructureSection load='3afc' size='340' side='right'caption='[[3afc]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='3afc' size='340' side='right'caption='[[3afc]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3afc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3afc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AFC FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3afc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3afc OCA], [https://pdbe.org/3afc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3afc RCSB], [https://www.ebi.ac.uk/pdbsum/3afc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3afc ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3afc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3afc OCA], [https://pdbe.org/3afc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3afc RCSB], [https://www.ebi.ac.uk/pdbsum/3afc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3afc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/SEM6A_MOUSE SEM6A_MOUSE] Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.<ref>PMID:16205717</ref> <ref>PMID:19063725</ref> <ref>PMID:20877282</ref> <ref>PMID:20881961</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Semaphorin|Semaphorin]] | *[[Semaphorin 3D structures|Semaphorin 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Mihara | [[Category: Mihara E]] | ||
[[Category: Nogi | [[Category: Nogi T]] | ||
[[Category: Takagi | [[Category: Takagi J]] | ||
[[Category: Yasui | [[Category: Yasui N]] | ||