Signal transduction: Difference between revisions
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*[[Hydroxysteroid dehydrogenase]] | *[[Hydroxysteroid dehydrogenase]] | ||
'''Sex steroids''' | |||
''[[Androgens]]'' | |||
An androgen is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. The major androgen in males is <scene name='89/895670/Cv/5'>testosterone</scene>. It is the primary sex hormone and anabolic steroid in males. It is a steroid from the androstane class. It exerts its action through binding to and activation of the [[androgen receptor]]. | An androgen is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. The major androgen in males is <scene name='89/895670/Cv/5'>testosterone</scene>. It is the primary sex hormone and anabolic steroid in males. It is a steroid from the androstane class. It exerts its action through binding to and activation of the [[androgen receptor]]. | ||
*[[Androgen receptor]]. Ligand binding domain (LBD) containing an <scene name='54/543362/Cv/3'>active site</scene> which binds intramolecularly the N-terminal FXXFL motif or coactivators with the same motif.<ref>PMID:18805694</ref> Water molecules are shown as red spheres. <scene name='89/895670/Cv/6'>Human androgen receptor bound to testosterone</scene> ([[2ylo]]). | *[[Androgen receptor]]. Ligand binding domain (LBD) containing an <scene name='54/543362/Cv/3'>active site</scene> which binds intramolecularly the N-terminal FXXFL motif or coactivators with the same motif.<ref>PMID:18805694</ref> Water molecules are shown as red spheres. <scene name='89/895670/Cv/6'>Human androgen receptor bound to testosterone</scene> ([[2ylo]]). | ||
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*Cytochrome P450 3A4 ([[CYP3A4]]) | *Cytochrome P450 3A4 ([[CYP3A4]]) | ||
[''[Estrogens]]'' | |||
There are three major endogenous estrogens that have estrogenic hormonal activity: estrone (E1), estradiol (E2), and estriol (E3). Estradiol, an estrane, is the most potent and prevalent. Another estrogen called estetrol (E4) is produced only during pregnancy. | There are three major endogenous estrogens that have estrogenic hormonal activity: estrone (E1), estradiol (E2), and estriol (E3). Estradiol, an estrane, is the most potent and prevalent. Another estrogen called estetrol (E4) is produced only during pregnancy. | ||
*[[Estrogen receptor]] | *[[Estrogen receptor]] | ||
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*[[3l03]] - Crystal Structure of human Estrogen Receptor alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II peptide and Estetrol (Estra-1,3,5(10)-triene-3,15 alpha,16alpha,17beta-tetrol) | *[[3l03]] - Crystal Structure of human Estrogen Receptor alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II peptide and Estetrol (Estra-1,3,5(10)-triene-3,15 alpha,16alpha,17beta-tetrol) | ||
''[[Progestogens]]'' | |||
'''Progesterone''' | '''Progesterone''' | ||
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*[[Hydroxysteroid dehydrogenase]], 20-α HSD is involved in the control of progesterone level in pregnancy of mice. 17-β HSD is involved in the conversion of androstenedione to testosterone. | *[[Hydroxysteroid dehydrogenase]], 20-α HSD is involved in the control of progesterone level in pregnancy of mice. 17-β HSD is involved in the conversion of androstenedione to testosterone. | ||
[[Vitamin D derivatives; secosteroids (open-ring steroids)]] | |||
<scene name='89/895670/Cv/9'>Vitamin D</scene>. | <scene name='89/895670/Cv/9'>Vitamin D</scene>. | ||