1fw6: Difference between revisions

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-[[Image:1fw6.gif|left|200px]]
+{{Seed}}
+[[Image:1fw6.png|left|200px]]
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 {{STRUCTURE_1fw6|  PDB=1fw6  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF A TAQ MUTS-DNA-ADP TERNARY COMPLEX'''
+===CRYSTAL STRUCTURE OF A TAQ MUTS-DNA-ADP TERNARY COMPLEX===
-==Overview==
+<!--
-The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also possess a conserved ATPase activity that belongs to the ATP binding cassette (ABC) superfamily. Here we report the crystal structure of a ternary complex of MutS-DNA-ADP and assays of initiation of mismatch repair in conjunction with perturbation of the composite ATPase active site by mutagenesis. These studies indicate that MutS has to bind both ATP and the mismatch DNA simultaneously in order to activate the other mismatch repair proteins. We propose that the MutS ATPase activity plays a proofreading role in DNA mismatch repair, verification of mismatch recognition, and authorization of repair.
+The line below this paragraph, {{ABSTRACT_PUBMED_11172706}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11172706 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11172706}}
 ==About this Structure==
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 [[Category: Multi-domain structure]]
 [[Category: Protein-dna complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:50:08 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 04:02:12 2008''