2dda: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2dda]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudechis_australis Pseudechis australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DDA FirstGlance]. <br> | <table><tr><td colspan='2'>[[2dda]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudechis_australis Pseudechis australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DDA FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dda OCA], [https://pdbe.org/2dda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dda RCSB], [https://www.ebi.ac.uk/pdbsum/2dda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dda ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dda OCA], [https://pdbe.org/2dda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dda RCSB], [https://www.ebi.ac.uk/pdbsum/2dda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dda ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CRVP_PSEAU CRVP_PSEAU] Blocks olfactory (CNGA2) and retinal (CNGA1) cyclic nucleotide-gated (CNG) ion channel currents. Does not inhibit retinal (CNGA3) currents. It forms high-affinity contacts with the pore turret region and most likely inhibits CNG channel current by blocking the external entrance to the transmembrane pore. Is really more potent that Pseudecin. Does not affect neither depolarization- nor caffeine-induced contraction arterial smooth muscle.<ref>PMID:12234174</ref> <ref>PMID:9892706</ref> <ref>PMID:14638933</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Pseudechis australis]] | [[Category: Pseudechis australis]] | ||
[[Category: Fujimoto | [[Category: Fujimoto Z]] | ||
[[Category: Mizuno | [[Category: Mizuno H]] | ||
[[Category: Morita | [[Category: Morita T]] | ||
[[Category: Suzuki | [[Category: Suzuki N]] | ||
[[Category: Yamazaki | [[Category: Yamazaki Y]] | ||