1cwo: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1cwo. | [[Image:1cwo.jpg|left|200px]]<br /><applet load="1cwo" size="450" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1cwo" size="450" color="white" frame="true" align="right" spinBox="true" | |||
caption="1cwo, resolution 1.86Å" /> | caption="1cwo, resolution 1.86Å" /> | ||
'''HUMAN CYCLOPHILIN A COMPLEXED WITH THR2, LEU5, D-HIV8, LEU10 CYCLOSPORIN'''<br /> | '''HUMAN CYCLOPHILIN A COMPLEXED WITH THR2, LEU5, D-HIV8, LEU10 CYCLOSPORIN'''<br /> | ||
| Line 8: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
1CWO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] | 1CWO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] Known structural/functional Site: <scene name='pdbsite=BIN:Cyclosporin Binding Site'>BIN</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CWO OCA]. | ||
==Reference== | ==Reference== | ||
| Line 21: | Line 20: | ||
[[Category: complex (isomerase/immunosuppressant)]] | [[Category: complex (isomerase/immunosuppressant)]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 14:43:40 2007'' | ||
Revision as of 15:33, 18 December 2007
|
HUMAN CYCLOPHILIN A COMPLEXED WITH THR2, LEU5, D-HIV8, LEU10 CYCLOSPORIN
OverviewOverview
The crystal structure of (Thr2, Leu5, d-Hiv8, Leu10)-cyclosporin (cyclic, peptolide SDZ 214-103) has been determined as the unbound crystal form and, as a complex with human cyclophilin A. This pair of structures provides an, example of a significant difference in conformation between free and bound, ligand in crystals. The conformation of the unbound form is unlike that of, both free and bound conformations of cyclosporin A (with the amide bond, between residues 3 and 4 in the cis conformation), while the bound, conformation is similar to that of CsA bound to cyclophilin. The, cyclophilin-bound conformations of both ligands are similar, though this, involves a significantly different waterellipsisligand hydrogen-bonding, structure, which compensates for the chemical differences between the two, ligands.
About this StructureAbout this Structure
1CWO is a Single protein structure of sequence from Homo sapiens. Active as Peptidylprolyl isomerase, with EC number 5.2.1.8 Known structural/functional Site: . Full crystallographic information is available from OCA.
ReferenceReference
Conformational differences of an immunosuppressant peptolide in a single crystal and in a crystal complex with human cyclophilin A., Mikol V, Taylor P, Kallen J, Walkinshaw MD, J Mol Biol. 1998 Oct 23;283(2):451-61. PMID:9769217
Page seeded by OCA on Tue Dec 18 14:43:40 2007